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Compared to traditional staining, our UCNP technology gives higher contrast and granularity resulting in a better image, but also a better quantification foundation. Our UCNP technology doesn’t produce disturbing backgrounds, which can happen when using traditional staining. Our UCNP technology enables the detection of low signals. Due to the two modalities of brightfield and UCNP-generated images, the user gets better images of the tissue morphology compared to the combination of haematoxylin and DAB combined in one channel.
When analysing melanoma samples, it’s important to be able to visualise specific markers in the tissue to diagnose and monitor the progression.
Our images combine traditional staining with our UCNP technology.
Traditional DAB staining makes it difficult to differentiate the stain from the natural melanin in the sample, as they are both brown. Our UCNP technology highlights the melanocytes that have a concentration of S100B, and they become easy to differentiate due to the possibility of selecting the colour of the UCNP signal, which leads to better contrast and a specific visualisation of the chosen marker.
A brightfield image of haematoxylin-stained cell nuclei and cells containing melanin.
A brightfield image of traditional DAB staining. Traditional DAB staining makes it difficult to differentiate melanin from the DAB-stained S100B.
The image shows S100B with UCNP staining. The image shows the possibility of selecting a working colour when using our UCNP technology, and that the UCNP modality is in a separate channel.
A brightfield image of haematoxylin-stained cell nuclei in blue and cells containing melanin in pink. This is combined with the UCNP-stained marker S100B in green.
PSMA (Prostate-specific Membrane Antigen) is a marker used for identifying and monitoring prostate cancer. To ensure a correct diagnosis of prostate cancer, it’s important to be able to visualise PSMA-labelled tissue in high-quality images.
Our images show PSMA-labelled prostate tissue from two different tissue segments taken from the same tumour. When using our UCNP technology to identify PSMA in the tissue samples, the advantages of higher contrast and granularity compared to traditional staining can be seen very clearly.
The first sample can be seen in a brightfield image of haematoxylin-stained cell nuclei and DAB staining of PSMA. The two stains are applied to the sample and cannot be viewed separately.
The second sample is seen in a brightfield image showing haematoxylin staining of cell nuclei in a separate channel.
The image shows the same sample as the second image, where UCNP has been used for PSMA labelling. The UCNP labelling is viewed in a different channel.
The image shows the second sample when the brightfield and UCNP channels have been combined to give one image detailing the tissue morphology as well as the UCNP PSMA labelling.
Ola Andersson
We have telephone hours on weekdays between 08:00 and 14:30. Closed for lunch 12-13.
Phone: +46(0)10-204 00 15
Mail: info@lumito.se
Lumito AB (publ)
Mårtenstorget 5, 223 51, Lund
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