Compared to traditional staining, our UCNP technology gives higher contrast and granularity resulting in a better image, but also a better quantification foundation. Our UCNP technology doesn’t produce disturbing backgrounds, which can happen when using traditional staining. Our UCNP technology enables the detection of low signals. Due to the two modalities of brightfield and UCNP-generated images, the user gets better images of the tissue morphology compared to the combination of haematoxylin and DAB combined in one channel.
When analysing melanoma samples, it’s important to be able to visualise specific markers in the tissue to diagnose and monitor the progression.
Our images combine traditional staining with our UCNP technology.
Traditional DAB staining makes it difficult to differentiate the stain from the natural melanin in the sample, as they are both brown. Our UCNP technology highlights the melanocytes that have a concentration of S100B, and they become easy to differentiate due to the possibility of selecting the colour of the UCNP signal, which leads to better contrast and a specific visualisation of the chosen marker.
PSMA (Prostate-specific Membrane Antigen) is a marker used for identifying and monitoring prostate cancer. To ensure a correct diagnosis of prostate cancer, it’s important to be able to visualise PSMA-labelled tissue in high-quality images.
Our images show PSMA-labelled prostate tissue from two different tissue segments taken from the same tumour. When using our UCNP technology to identify PSMA in the tissue samples, the advantages of higher contrast and granularity compared to traditional staining can be seen very clearly.