We have developed the next-generation IHC tissue analysis system, based on upconverting nanoparticles (UCNPs). The Lumito SCIZYS is a cutting-edge, high-sensitivity system combining labeling and imaging technologies to locate and measure biomarkers in tissue samples.
Struggling to quantify low‑abundance biomarkers in tissue? SCIZYS enables ultra‑sensitive, autofluorescence‑free detection, with a wide dynamic range in a single image. Move beyond visual scoring.
Detection down to single labels using photon-upconverting nanoparticles
Chromogenic counterstain and biomarker information in fully separated channels from the same sample
High-accuracy quantification based on uniform nanoparticle light quanta and a wide dynamic range detection system
Ultrasensitive HER2‑low detection
Measuring very low HER2 can be challenging with standard tissue methods. In our recent white paper we show how SCIZYS delivers up to 12× higher sensitivity and a broader dynamic range than traditional methods. We show how we can measure HER2 at levels that enable differentiation between HER2‑low and HER2‑negative tissue.
Ultrasensitive Immunohistochemistry with SCIZYS
Detecting low-abundance biomarkers in tissue can be difficult with conventional methods. SCIZYS uses photon-upconversion nanoparticles (UCNPs) to eliminate tissue autofluorescence, achieve single-particle sensitivity, and provide exceptional photostability. The system enables precise detection of biomarkers like HER2 and PD-L1 at very low levels, offering a broader dynamic range and highly sensitive quantification for IHC applications.
Lumito provides a complete workflow solution for ultra-sensitive tissue biomarker detection — from sample preparation to cloud-based image analysis.
1. Prepare IHC slides
Use standard immunohistochemistry protocols.
2. Add SCIZYS detection reagents
3. Send IHC slides to us for scanning
Images histological samples using:
4. Access and analyze data
You get access to the images in a browser based viewer, images can be analyzed directly or downloaded in standard ome-tiff format for further off-line analysis.
Research Use Only (RUO). Not for clinical or diagnostic use.
For research teams interested in evaluating the platform.