Increasing objectivity in tissue analysis

We have developed the next-generation IHC tissue analysis system, based on upconverting nanoparticles (UCNPs). The Lumito SCIZYS is a cutting-edge, high-sensitivity system combining labeling and imaging technologies to locate and measure biomarkers in tissue samples.

Overcoming limitations in tissue biomarker detection

Struggling to quantify low‑abundance biomarkers in tissue? SCIZYS enables ultra‑sensitive, autofluorescence‑free detection, with a wide dynamic range in a single image. Move beyond visual scoring.

Ultra-sensitive detection

Detection of single labels from photon-upconverting nanoparticles

Full biomarker and morphology separation

Chromogenic counterstain and biomarker information in fully separated channels from the same sample

Exceptional dynamic range

High-accuracy quantification based on uniform nanoparticle light quanta and a wide dynamic range detection system

Scientific validation

Ultrasensitive HER2‑low detection

Measuring very low HER2 can be challenging with standard tissue methods. Our new white paper shows how SCIZYS delivers up to 12× higher sensitivity, a broader dynamic range, and can measure HER2 at levels that enable differentiation between HER2‑low and HER2‑negative tissue.

Ultra-sensitive tissue biomarker detection

Low-level analyte detection can be difficult with conventional IHC. Our white paper shows how SCIZYS enables autofluorescence-free, ultra-sensitive detection with high photostability and extended dynamic range for advanced tissue analysis.

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Här tänker jag att vi kan välja ut två till vetenskapliga artiklar eller annat så man förstår att det inte bara kan användas för HER2?

SCIZYS workflow platform

Lumito provides a complete workflow solution for ultra-sensitive tissue biomarker detection — from sample preparation to cloud-based image analysis.

  1. Prepare IHC slides
    Use standard immunohistochemistry protocols.
  2. Add SCIZYS detection reagents
    • Uses upconverting nanoparticle (UCNP) technology

    • Enables identification of biotinylated primary or secondary antibodies

    • Improves detection of biological markers in tissue samples

  3. Send IHC slides to us for scanning
    Images histological samples using:

    • Brightfield imaging

    • UCNP luminescence detection

  4. Access and analyze data
    You receive OME-TIFF image files that can be viewed and analyzed using browser-based tools.

Research Use Only (RUO). Not for clinical or diagnostic use.

Request a technical discussion

For research teams interested in evaluating the platform.